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Capsule Cracking Effects During Large-Scale Filling of Hygroscopic Liquid Materials into Hard Gelati

Released By Thermo Fisher Scientific Pharma Services

The purpose of this study was to understand the influence of capsule design, manufacturing scale, storage condition (humidity) and hygroscopicity on cracking of liquid filled hard gelatin capsules (LFHC). This study confirms that liquid filled hard gelatin capsule cracking is associated with capsule design.

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